大象传媒

Abstract

Organophosphonates (Pns) comprise a prominent class of natural products that is defined by a highly stable C-P bond. The biochemistry of Pns has evolved into two worlds, with one dedicated to synthesizing the C鈭扨 bond and incorporating this motif into complex bioactive molecules, while the other seeks to cleave the C鈭扨 bond to release inorganic phosphate, a life limiting nutrient. Non-heme iron dependent oxygenases play important roles in both biosynthetic and catabolic Pn pathways. This seminar will cover (1) recent mechanistic studies into the oxidative C-P bond cleavage reaction catalyzed by the mixed valence diiron oxygenase, PhnZ, and (2) the unusual transformations catalyzed by a non-heme iron / alpha-ketoglutarate dependent oxygenase during the biosynthesis of the fungal metabolite, Fosfonochlorin.