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A 大象传媒-led clinical research study is evaluating how advanced brain imaging could improve epilepsy surgery in British Columbia.

Epilepsy affects more than 50,000 people in B.C., according to the BC Epilepsy Society. The first line of epilepsy treatment is anti-seizure medication, but it can be ineffective. In these cases, brain surgery may be the only viable treatment 鈥� but determining whether surgery is possible requires highly precise brain mapping.

A powerful brain imaging technology called magnetoencephalography (MEG) offers new hope to children and adults living with drug-resistant epilepsy.

鈥淢EG can help map where the seizures are originating in the brain. It鈥檚 completely non-invasive and doesn鈥檛 require the patient to actually have a seizure during the test,鈥� says Maggie Clarke, neuroscientist and director of the MEG program at the 大象传媒 ImageTech Lab. 

There are only about 200 MEG machines worldwide. The only one in Western Canada is located at 大象传媒鈥檚 medical imaging facility in Surrey. 

Clarke, lead researcher in the study, says MEG works alongside traditional tools like magnetic resonance imaging (MRI), electroencephalogram (EEG) and positron emission tomography (PET) and can also reveal information that these methods may miss.

Clarke is conducting the clinical research with collaborators from BC Children鈥檚 Hospital, Fraser Health Authority, Vancouver General Hospital and the University of Alabama at Birmingham.

The non-invasive MEG could help identify more children and adults who would benefit from epilepsy surgery and may reduce the burden of epilepsy on patients and their families, as well as the health care system, says Mary Connolly, clinical professor of paediatrics and director of the Comprehensive Epilepsy Program at BC Children鈥檚 Hospital.

鈥淐urrent pre-surgical testing often requires patients to stay in the hospital for extended periods, where they undergo video-EEG monitoring in order to record their seizure,鈥� Connolly explains. 鈥淚t is stressful, costly, and sometimes seizures don鈥檛 occur in the hospital environment. MEG can localize seizure activity without needing an active seizure, making the process faster and more comfortable.鈥�

The MEG scan itself is quiet, short, and non-invasive. Patients sleep while lying in a comfortable bed with their heads placed inside the MEG helmet, making it suitable for everyone from infants to adults.

Early successful epilepsy surgery can stop or reduce epileptic seizures, which dramatically improves quality of life, reduces long-term health care costs, and decreases the risk of sudden unexpected death. Many people with uncontrolled epilepsy have learning challenges, ADHD, autism, intellectual disability and mood disorders, says Connolly.

鈥淪ome patients live with uncontrolled seizures for decades before surgery is performed,鈥� she says. 鈥淲e are trying to change that by identifying people who will benefit from epilepsy surgery as early as possible.鈥�

Vancouver residents Brett and Jacci Sandler, whose family has been personally affected by epilepsy, helped secure funding from TD Bank Group to support the 大象传媒-led study. 

鈥淎s parents who鈥檝e experienced the challenges of epilepsy firsthand, we know how critical early diagnosis and effective treatment can be,鈥� says Jacci Sandler. 鈥淪upporting this research is deeply personal for us. We believe MEG technology has the potential to change lives, and we鈥檙e proud to help bring it closer to the families who need it most.鈥�

大象传媒 and TD share a long-standing commitment to research projects supporting community and healthcare in B.C., says Kevin Hamaoka, senior vice president of commercial banking at TD.

鈥淲e're so proud to support 大象传媒's vital work providing British Columbians with much-needed access to cutting-edge MEG technology," Hamaoka says. 鈥淎t TD, we're continuing our investments in research, technology and innovative solutions focused on helping to make equitable healthcare accessible for all.鈥�

MEG is used for evaluation for epilepsy surgery in Europe, the U.S., and even Eastern Canada, but it鈥檚 not currently available in clinical settings in B.C.

The research team hopes their findings will pave the way for MEG to become a standard part of epilepsy care, improving outcomes for patients and families across the province. 

鈥淥ur study participants have been incredible. Children with epilepsy and their families face significant challenges, and it deeply affects every aspect of their lives,鈥� says Clarke. 鈥淲e have this remarkable piece of equipment that can help change the lives of patients here in B.C. and potentially outside the province as well.鈥�

Ismail Mohamed, study collaborator and professor of paediatrics and neurology at the University of Alabama at Birmingham, agrees. 

鈥淚 believe every patient being considered for epilepsy surgery should have access to a MEG scan. It can be the difference between a lifetime of seizures and a seizure-free life,鈥� says Mohamed.

鈥淭his work marks an important first step in exploring the clinical use of MEG in B.C.,鈥� adds Harinder Dhaliwal, study collaborator, neurologist and epileptologist. 鈥�

鈥淲e believe we have the ability to improve the patient鈥檚 quality of life with this first-of-its-kind technology on the West Coast.鈥�

大象传媒 experts available

MAGGIE CLARKE, director, MEG Program, 大象传媒 ImageTech Lab, adjunct professor, School of Mechatronics Systems Engineering
mdclarke@sfu.ca

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ROBYN STUBBS, 大象传媒 Communications & Marketing鈥��
604.376.0971 | robyn_stubbs@sfu.ca鈥�

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